Calcium Influx Guards Replication Forks against Exonuclease 1

Antoine Simoneau; Lee Zou

doi:10.1016/j.molcel.2019.06.005

Calcium Influx Guards Replication Forks against Exonuclease 1

Mol Cell. 2019 Jun 20;74(6):1103-1105. doi: 10.1016/j.molcel.2019.06.005.

Authors

Antoine Simoneau¹, Lee Zou²

Affiliations

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
² Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: zou.lee@mgh.harvard.edu.

PMID: 31226273
DOI: 10.1016/j.molcel.2019.06.005

Abstract

In this issue, Li et al. (2019) report a previously unknown Ca²⁺-CaMKK2-AMPK signaling cascade that protects stalled forks from degradation by phosphorylating and inhibiting the EXO1 nuclease, revealing a surprising role for Ca²⁺ influx in the maintenance of genomic stability.

Publication types

Comment

MeSH terms

AMP-Activated Protein Kinases*
Calcium*
DNA Replication
Exodeoxyribonucleases
Phosphorylation

Substances

AMP-Activated Protein Kinases
Exodeoxyribonucleases
exodeoxyribonuclease I
Calcium