Data on somatic mutations obtained by whole exome sequencing of FFPE tissue samples from Russian patients with prostate cancer

A S Nikitina; E I Sharova; S A Danilenko; O V Selezneva; L O Skorodumova; A V Kanygina; K A Babalyan; A O Vasiliev; A V Govorov; E A Prilepskaya; D Y Pushkar; E S Kostryukova; E V Generozov

doi:10.1016/j.dib.2019.104022

Data on somatic mutations obtained by whole exome sequencing of FFPE tissue samples from Russian patients with prostate cancer

Data Brief. 2019 May 24:25:104022. doi: 10.1016/j.dib.2019.104022. eCollection 2019 Aug.

Authors

Affiliations

¹ Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia.
² Moscow Institute of Physics and Technology, Dolgoprudnyi, Russia.
³ Department of Urology, Moscow State Medical Stomatological University, Moscow, Russia.

Abstract

Prostate cancer (PCa) is the most frequently diagnosed among men malignant disease that remains poorly characterized at the molecular level. Advanced PCa is not curable, and the current treatment methods can only increase the life expectancy by several months. Identification of the genetic aberrations in tumor cells provides clues to understanding the mechanisms of PCa pathogenesis and the basis for developing new therapeutic approaches. Here we present data on somatic mutations, namely single nucleotide variations (SNVs), small insertions and deletions, detected in prostate tumor tissue obtained from Russian patients with PCa. Moreover, we provide a raw dataset on the whole exome and targeted DNA sequencing of tumor and non-tumor prostate tissue obtained from Russian patients with PCa and benign prostatic hyperplasia (BPH). This data is available at NCBI Sequence Read Archive under Accession No. PRJNA506922.

Keywords: Prostate cancer; Somatic variants; Whole exome.