Natural history and cell of origin of TC F3- ZN F384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL

Blood. 2019 Sep 12;134(11):900-905. doi: 10.1182/blood.2019000893. Epub 2019 Jun 20.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Cell Lineage / genetics
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 19 / genetics
  • Disease Progression
  • Diseases in Twins* / genetics
  • Diseases in Twins* / pathology
  • Hematopoietic Stem Cells / metabolism*
  • Hematopoietic Stem Cells / pathology
  • Humans
  • Infant
  • Molecular Diagnostic Techniques
  • Mutation
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics*
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11 / metabolism
  • Trans-Activators / genetics*
  • Trans-Activators / metabolism
  • Translocation, Genetic
  • Twins, Monozygotic*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Oncogene Proteins, Fusion
  • TCF3 protein, human
  • Trans-Activators
  • ZNF384 protein, human
  • PTPN11 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11