Betulin and its derivatives as novel compounds with different pharmacological effects

Shayan Amiri; Sanaz Dastghaib; Mazaher Ahmadi; Parvaneh Mehrbod; Forough Khadem; Hamid Behrouj; Mohamad-Reza Aghanoori; Filip Machaj; Mahdi Ghamsari; Jakub Rosik; Andrzej Hudecki; Abbas Afkhami; Mohammad Hashemi; Marek J Los; Pooneh Mokarram; Tayyebeh Madrakian; Saeid Ghavami

doi:10.1016/j.biotechadv.2019.06.008

Betulin and its derivatives as novel compounds with different pharmacological effects

Biotechnol Adv. 2020 Jan-Feb:38:107409. doi: 10.1016/j.biotechadv.2019.06.008. Epub 2019 Jun 18.

Authors

Shayan Amiri¹, Sanaz Dastghaib², Mazaher Ahmadi³, Parvaneh Mehrbod⁴, Forough Khadem⁵, Hamid Behrouj², Mohamad-Reza Aghanoori⁶, Filip Machaj⁷, Mahdi Ghamsari³, Jakub Rosik⁷, Andrzej Hudecki⁸, Abbas Afkhami³, Mohammad Hashemi⁹, Marek J Los¹⁰, Pooneh Mokarram², Tayyebeh Madrakian³, Saeid Ghavami¹¹

Affiliations

¹ Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
² Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
³ Department of Analytical Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
⁴ Influenza and Respiratory Viruses Department, Pasteur Institute of IRAN, Tehran, Iran.
⁵ Department of Immunology, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
⁶ Division of Neurodegenerative Disorders, St Boniface Hospital Albrechtsen Research Centre, Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada.
⁷ Department of Pathology, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-344 Szczecin, Poland.
⁸ Institue of Non-Ferrous Metals, ul. Sowińskiego 5, 44-100 Gliwice, Poland.
⁹ Department of Clinical Biochemistry, Zahedan University of Medical Science, Zahedan, Iran.
¹⁰ Biotechnology Center, Silesian University of Technology, ul Bolesława Krzywoustego 8, Gliwice, Poland; Linkocare Life Sciences AB, Teknikringen 10, Plan 3, 583 30 Linköping, Sweden.
¹¹ Department of Human Anatomy and Cell Science, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran; Research Institute of Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Canada. Electronic address: saeid.ghavami@umanitoba.ca.

PMID: 31220568
DOI: 10.1016/j.biotechadv.2019.06.008

Abstract

Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids which possess a wide range of pharmacological activities. Recent evidence indicates that B and BA have several properties useful for the treatment of metabolic disorders, infectious diseases, cardiovascular disorders, and neurological disorders. In the current review, we discuss B and BA structures and derivatives and then comprehensively explain their pharmacological effects in relation to various diseases. We also explain antiviral, antibacterial and anti-cancer effects of B and BA. Finally, we discuss the delivery methods, in which these compounds most effectively target different systems.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Bacterial Agents
Antiviral Agents
Triterpenes / chemistry*

Substances

Anti-Bacterial Agents
Antiviral Agents
Triterpenes
betulin