Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

Xiangyi Kong; Jie Zhai; Chengrui Yan; Yan Song; Jing Wang; Xiaofeng Bai; James A L Brown; Yi Fang

doi:10.3389/fonc.2019.00234

Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

Front Oncol. 2019 May 31:9:234. doi: 10.3389/fonc.2019.00234. eCollection 2019.

Authors

Xiangyi Kong¹, Jie Zhai¹, Chengrui Yan², Yan Song³, Jing Wang¹, Xiaofeng Bai⁴, James A L Brown^{5

6}, Yi Fang¹

Affiliations

¹ Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Neurosurgery, Peking University International Hospital, Beijing, China.
³ Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴ Department of Pancreatic-Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁵ Discipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland.
⁶ Centre for Chromosome Biology, National University of Ireland in Galway, Galway, Ireland.

Abstract

FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.

Keywords: FOXN3; breast; cancer; forkhead; function; malignancy; regulation; review.

Publication types

Review