A Rationale for Change: An Increase in Invasive Pneumococcal Disease in Fully Vaccinated Children

Christopher C Blyth; Sanjay Jayasinghe; Ross M Andrews

doi:10.1093/cid/ciz493

A Rationale for Change: An Increase in Invasive Pneumococcal Disease in Fully Vaccinated Children

Clin Infect Dis. 2020 Feb 3;70(4):680-683. doi: 10.1093/cid/ciz493.

Authors

Christopher C Blyth^{1

2

3}, Sanjay Jayasinghe^{4

5}, Ross M Andrews^{6

7}

Affiliations

¹ School of Medicine, University of Western Australia, Perth.
² Perth Children's Hospital, Nedlands.
³ Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, West Perth.
⁴ National Centre for Immunisation Research and Surveillance for Vaccine Preventable Diseases, Westmead.
⁵ Discipline of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney.
⁶ Menzies School of Health Research, Charles Darwin University, Darwin.
⁷ National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.

PMID: 31209491
DOI: 10.1093/cid/ciz493

Abstract

Increasing numbers of cases of invasive pneumococcal disease in fully vaccinated children have occurred in Australia since 2013. A review of cases informed a change from a "3 + 0" infant schedule (13-valent pneumococcal conjugate vaccine at 2, 4, and 6 months) to a "2 + 1" schedule (2, 4, and 12 months).

Keywords: infant; pneumococcus; vaccination.

Publication types

Review

MeSH terms

Australia / epidemiology
Child
Humans
Immunization Schedule
Infant
Pneumococcal Infections* / epidemiology
Pneumococcal Infections* / prevention & control
Pneumococcal Vaccines
Vaccines, Conjugate

Substances

Pneumococcal Vaccines
Vaccines, Conjugate