A nanocomposite fluorescent probe based on fluorescence quenching was fabricated and utilized for the detection of lomefloxacin. The fabricated probe integrated the high sensitivity of quantum dots, the excellent selectivity of molecularly imprinted polymer and the high adsorption affinity of graphene oxide and polyaniline. The probe exhibited good sensitivity, high specificity, and rapidity for lomefloxacin monitoring. Fluorescence emission was reduced linearly by lomefloxacin from 0.10 to 50.0 μg L-1 and the probe exhibited a low limit of detection of 0.07 μg L-1. The nanooptosensor successfully detected lomefloxacin in milk, chicken meat and egg samples. Recoveries were obtained in the range of 81.5-99.6% and the RSDs were below 7%. The results of this method agreed well with results of HPLC but provided higher sensitivity. This easily fabricated nanocomposite probe could be developed into a highly sensitive and selective optosensor to detect other organic compounds in various complex samples.
Keywords: Graphene oxide; Lomefloxacin; Molecularly imprinted polymer; Polyaniline; Quantum dots.
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