PEGylated cyanine dye nanoparticles as photothermal agents for mosquito and cancer cell control

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2398-2404. doi: 10.1016/j.bmcl.2019.05.057. Epub 2019 May 30.

Abstract

Conversion of light energy to heat via photothermal conversion agents (PTCAs) is of great interest and has potential applications. Here, we described a heptamethine cyanine (Cy7) dye nanoparticles (Cy7-PEG NPs) prepared from heptamethine cyanine and poly(ethylene glycol) (PEG400) via a simple solvothermal process as novel PTCA. Cy7-PEG NPs have absorption maximum at about 808 nm and good photothermal conversion ability. Upon irradiation, Cy7-PEG NPs can effectively kill living mosquito larva (Aedes albopictus) through heat generation. Furthermore, Cy7-PEG NPs have excellent phototoxic activity to Sf9, HeLa and MCF-7 cells. Our results indicated that Cy7-PEG NPs can be used as controlling agent for mosquito larvae and cancer cells.

Keywords: Mosquito larvae; Nanoparticles; PEGylated; Photothermal; Phototoxic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzothiazoles / chemistry
  • Benzothiazoles / pharmacology*
  • Carbocyanines / chemistry
  • Carbocyanines / pharmacology*
  • Cell Survival / drug effects
  • Culicidae / drug effects*
  • Dose-Response Relationship, Drug
  • HeLa Cells
  • Humans
  • MCF-7 Cells
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Particle Size
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Phototherapy*
  • Polyethylene Glycols / chemistry
  • Polyethylene Glycols / pharmacology*
  • Sf9 Cells
  • Spodoptera
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Benzothiazoles
  • Carbocyanines
  • Photosensitizing Agents
  • Polyethylene Glycols
  • cyanine dye 7
  • polyethylene glycol 400