Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells

Alexey V Solomonov; Yuriy S Marfin; Evgeniy V Rumyantsev; Elena Ragozin; Talia Shekhter Zahavi; Gary Gellerman; Alexander B Tesler; Falk Muench; Akiko Kumagai; Atsushi Miyawaki

doi:10.1016/j.dib.2019.104052

Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells

Data Brief. 2019 May 24:25:104052. doi: 10.1016/j.dib.2019.104052. eCollection 2019 Aug.

Authors

Affiliations

¹ Inorganic Chemistry Department, Ivanovo State University of Chemistry and Technology, 7 Sheremetevskij prosp., 153000, Ivanovo, Russian.
² Ivanovo State Polytechnical University, 21 Sheremetevskij prosp., 153000, Ivanovo, Russian.
³ Department of Chemical Sciences, Ariel University of Samaria, Ariel, Israel.
⁴ Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
⁵ Department of Materials and Interfaces, Faculty of Chemistry, Weizmann Institute of Science, 76100, 234 Herzl Street, Rehovot, Israel.
⁶ Department of Materials and Earth Sciences, Technische Universität Darmstadt, Alarich-Weiss-Strasse 2, 64287, Darmstadt, Germany.
⁷ Centre of Brain Science, Laboratory for Cell Function and Dynamics, RIKEN, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.

Abstract

The data presented here refer to a research article entitled "Self-Assembled Micellar Clusters Based on Triton-X-family Surfactants for Enhanced Solubilization, Encapsulation, Proteins Permeability Control, and Anticancer Drug Delivery" Solomonov et al., 2019. The present article provides the General Procedure for clusterization of Triton-X-based micelles and the effect of (i) metal ion, surfactant, and chelator concentration on the developed clusters formation, (ii) surfactant-chelator relation change, (iii) metal ion-micelles concertation ratio variation, (iv) metal ion replacement, (v) solvent replacement, (vi) kinetics of clusters formation, (vii) hydrophobic fluorescent dye (Coumarin 6) solubilization in aqueous MCs media, (viii) novel anticancer peptidyl drug synthesis and characterization and (ix) the viability of HeLa cells with and without the presence of drug-free Triton-X-based family MCs. These data provide additional insights useful for understanding all aspects of the micellar clusters formation, optimization, and control.

Keywords: Anticancer drug synthesis; Encapsulation; Fluorescence enhancement; Micellar clusters; Self-assembly; Surfactants; Triton-X.