Draft Genome Sequence of FK506-Producing Streptomyces tsukubensis Strain VKM Ac-2618D

Veronika Y Poshekhontseva; Eugeny Y Bragin; Victoria V Fokina; Victoriya Y Shtratnikova; Irina P Starodumova; Sergey V Tarlachkov; Marina V Donova

doi:10.1128/MRA.00510-19

Draft Genome Sequence of FK506-Producing Streptomyces tsukubensis Strain VKM Ac-2618D

Microbiol Resour Announc. 2019 Jun 13;8(24):e00510-19. doi: 10.1128/MRA.00510-19.

Authors

Veronika Y Poshekhontseva^{1

2}, Eugeny Y Bragin¹, Victoria V Fokina³, Victoriya Y Shtratnikova⁴, Irina P Starodumova¹, Sergey V Tarlachkov^{1

5}, Marina V Donova^{1

6}

Affiliations

¹ G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Federal Research Center, Pushchino, Russia.
² Pushchino State Natural Science Institute, Pushchino, Russia.
³ G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences, Federal Research Center, Pushchino, Russia 2vvfokina@gmail.com.
⁴ Department of Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, Moscow, Russia.
⁵ Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
⁶ Pharmins, Ltd., R&D, Pushchino, Russia.

Abstract

The 23-membered macrolide tacrolimus (FK506) is an important immunosuppressant that is widely used in the prevention of graft rejection and in the treatment of inflammatory skin diseases and immune diseases. We report here the draft genome sequence of the FK506 producer Streptomyces tsukubensis VKM Ac-2618D.