Amplifying mTORC2 signals through AMPK during energetic stress

Sci Signal. 2019 Jun 11;12(585):eaax5855. doi: 10.1126/scisignal.aax5855.

Abstract

Growth factors activate mTOR complex 2 (mTORC2) through poorly defined mechanisms to modulate cell metabolism. In this issue of Science Signaling, Kazyken et al. now report that AMPK directly activates mTORC2 during energetic stress to enhance cell survival.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • AMP-Activated Protein Kinases*
  • Cell Survival
  • Mechanistic Target of Rapamycin Complex 2
  • Signal Transduction
  • TOR Serine-Threonine Kinases*

Substances

  • Mechanistic Target of Rapamycin Complex 2
  • TOR Serine-Threonine Kinases
  • AMP-Activated Protein Kinases