Growth factors activate mTOR complex 2 (mTORC2) through poorly defined mechanisms to modulate cell metabolism. In this issue of Science Signaling, Kazyken et al. now report that AMPK directly activates mTORC2 during energetic stress to enhance cell survival.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.