CRISPR-Mediated Gene Editing: Scientific and Ethical Issues

Jarrod Bailey

doi:10.1016/j.tibtech.2019.05.002

CRISPR-Mediated Gene Editing: Scientific and Ethical Issues

Trends Biotechnol. 2019 Sep;37(9):920-921. doi: 10.1016/j.tibtech.2019.05.002. Epub 2019 Jun 7.

Author

Jarrod Bailey¹

Affiliation

¹ Cruelty Free International, 16a Crane Grove, London, N7 8NN, UK. Electronic address: Jarrod.bailey@crueltyfreeinternational.org.

PMID: 31182244
DOI: 10.1016/j.tibtech.2019.05.002

Abstract

There remains substantial evidence to warrant great concern over the poor efficiency and specificity of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic modification (GM), despite relatively minor improvements compared to other GM methods. These issues cause persistent, adverse, ethical, and scientific consequences for GM animals, which may never be sufficiently resolvable.

Keywords: CRISPR; gene therapy; genetically modified animals; genome editing.

Publication types

Letter

MeSH terms

Animals
Animals, Genetically Modified
CRISPR-Cas Systems*
Gene Editing / ethics*
Gene Editing / methods*
Genetic Engineering
Genome