Evaluation of Antitumor Efficiency of High Intensity Radiation 169Yb Source on Experimental Sarcoma M-1

S E Ulyanenko; S N Koryakin; A A Lychagin; M N Kuznetsova; V I Potetnya; L N Ulyanenko; A I Brovin

doi:10.1007/s10517-019-04466-4

Evaluation of Antitumor Efficiency of High Intensity Radiation ¹⁶⁹Yb Source on Experimental Sarcoma M-1

Bull Exp Biol Med. 2019 May;167(1):84-86. doi: 10.1007/s10517-019-04466-4. Epub 2019 Jun 8.

Authors

S E Ulyanenko¹, S N Koryakin², A A Lychagin¹, M N Kuznetsova¹, V I Potetnya¹, L N Ulyanenko¹, A I Brovin¹

Affiliations

¹ A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
² A. F. Tsyb Medical Radiological Research Center, Affiliated Branch of the National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia. korsenic@mail.ru.

PMID: 31177461
DOI: 10.1007/s10517-019-04466-4

Abstract

Rats with sarcoma M-1 were exposed to high dose rate irradiation with ¹⁶⁹Yb source. In 25 days after introduction of a trocar with sealed capsule with ¹⁶⁹Yb source into the tumor, complete tumor regression was observed in 70% animals. The results suggest feasibility of using ¹⁶⁹Yb source for high-dose rate brachytherapy and development of the personalized medicine approaches.

Keywords: Ytterbium-169; antitumor efficacy; high-dose rate brachytherapy; sarcoma М-1.

MeSH terms

Animals
Area Under Curve
Brachytherapy / methods*
Male
Rats
Sarcoma, Experimental / radiotherapy*
Ytterbium / therapeutic use*

Substances

Ytterbium