The Sphingosine-1-Phosphate Receptor Modulator Fingolimod Aggravates Murine Epidermolysis Bullosa Acquisita

J Invest Dermatol. 2019 Nov;139(11):2381-2384.e3. doi: 10.1016/j.jid.2019.03.1159. Epub 2019 Jun 7.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantibodies / metabolism
  • Autoimmune Diseases / drug therapy*
  • Cells, Cultured
  • Collagen Type VII / immunology
  • Disease Models, Animal
  • Epidermolysis Bullosa Acquisita / drug therapy*
  • Fingolimod Hydrochloride / pharmacology
  • Fingolimod Hydrochloride / therapeutic use*
  • Forkhead Transcription Factors / metabolism
  • Humans
  • Inflammation
  • Interleukin-10 / metabolism
  • Intraepithelial Lymphocytes / immunology*
  • Mice
  • Neutrophils / immunology*
  • Skin / drug effects*
  • Skin / pathology
  • Sphingosine-1-Phosphate Receptors / antagonists & inhibitors
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Autoantibodies
  • Collagen Type VII
  • Forkhead Transcription Factors
  • Foxp3 protein, mouse
  • Sphingosine-1-Phosphate Receptors
  • Interleukin-10
  • Fingolimod Hydrochloride