[Side effects of chemotherapy for testicular cancers and post-cancer follow-up]

Bull Cancer. 2019 Sep;106(9):805-811. doi: 10.1016/j.bulcan.2019.04.004. Epub 2019 Jun 4.
[Article in French]

Abstract

Testicular cancers are the most frequent and the most curable cancers in young men. Treatments of these cancers represent a great success with cure rate over to 95 %. However, chemotherapy side effects may occur during or after several years post-treatment. This review aimed to highlight complications and physical and psychological side effects occurring mainly after chemotherapy treatment for testicular cancer, and to propose a personalized post-cancer plan specific for patients treated for testicular cancer. Treatments of these cancers can cause short-term complications (asthenia, nausea, vomiting, alopecia..). These side effects disappear within a few months after the end of the treatments. Late complications may occur several years post-treatment. Cardiovascular disease, metabolic syndrome and secondary neoplasia represent the most severe late effects among patients treated for testicular cancer. Given the increased incidence of these chemotherapy-induced side effects, it is indispensable to establish a specific follow up which must include a particular vigilance on the risk of occurrence of second cancer, a follow-up of the cardio-vascular risk factors, pulmonary and auditory follow-up, and early detection of psychosocial disorders.

Keywords: Cancer du testicule; Chemotherapy; Chimiothérapie; Effets secondaires; Effets tardifs; Late effects; Side effects; Testicular cancer.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Cardiovascular Diseases / chemically induced
  • Cognition / drug effects
  • Cognition Disorders / chemically induced
  • Fatigue Syndrome, Chronic / chemically induced
  • Fertility / drug effects
  • Follow-Up Studies
  • Humans
  • Infertility, Male / chemically induced
  • Infertility, Male / prevention & control
  • Lung Diseases / chemically induced
  • Male
  • Metabolic Syndrome / chemically induced
  • Neoplasms, Second Primary / chemically induced
  • Nervous System Diseases / chemically induced
  • Testicular Neoplasms / drug therapy*
  • Testicular Neoplasms / psychology
  • Time Factors

Substances

  • Antineoplastic Agents