Bisphosphonates can directly inhibit osteoclasts, which may lead to increased bone density, reduced blood flow, and osteonecrosis of the jaw. Bisphosphonate-related osteonecrosis is usually observed in the jaw bone. In this article, we report a patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ) complicated with wrist scaphoid osteomyelitis. Furthermore, we introduce the pathogenesis, treatment, and prevention of BRONJ.
双膦酸盐类药物可以抑制破骨细胞功能，使颌骨骨密度升高，血流减少，发生骨坏死。双膦酸盐类药物相关性骨坏死多发于颌骨。本文报道1例双膦酸盐相关性颌骨坏死并发腕部舟状骨骨髓炎，并结合文献讨论双膦酸盐药物性颌骨坏死的发病机制、治疗与预防等。.
Keywords: bisphosphonate; osteonecrosis of the jaw; scaphoid osteomyelitis; zoledronic acid.