Abstract
A novel ergostane, sarocladione (1), was isolated from the deep-sea-derived fungus Sarocladium kiliense, along with 20 known compounds. The structure of 1 was determined mainly by a detailed analysis of its experimental and calculated NMR spectroscopic data. It is worth noting that 1 was the first steroid bearing a 5,10:8,9-diseco moiety. All 21 compounds were tested for in vitro antitumor activities against five cancer cell lines. β-Sitostenone (7) and 4,6-dihydroxyeudesmane (20) showed significant effects on HeLa-S3 cells with the IC50 values of 9.2 μM and 9.3 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acremonium / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Molecular Conformation
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Secosteroids / chemistry
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Secosteroids / isolation & purification
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Secosteroids / pharmacology*
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Steroids / chemistry
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Steroids / isolation & purification
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Steroids / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Secosteroids
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Steroids
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sarocladione