The title compound, (E,E)-3-methyl-2,5-bis-(4-methyl-benzyl-idene)cyclo-penta-none (MBMCP), C22H22O, was obtained by Claisen-Schmidt condensation of 4-methyl-benzaldehyde with 3-methyl-cyclo-penta-none in good yield. The structure of MBMCP was studied using UV, FT-IR and Raman spectroscopy, single-crystal X-ray diffraction (XRD) measurements, and 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The mol-ecular structure of MBMCP is fully extended in the E,E configuration. C-H⋯π stacking inter-actions play a significant role in the stabilization of the mol-ecular packing. Hirshfeld surface analysis was used to qu-antify the non-covalent inter-actions in the crystal lattice. Microbiological studies were performed to investigate the anti-microbial activity of this new product.
Keywords: Claisen–Schmidt reaction; crossed-aldol condensation; crystal structure; spectroscopic studies.