Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines

Helena Teede; Marie Misso; Eliza C Tassone; Didier Dewailly; Ernest Hy Ng; Ricardo Azziz; Robert J Norman; Marianne Andersen; Stephen Franks; Kathleen Hoeger; Samantha Hutchison; Sharon Oberfield; Duru Shah; Femke Hohmann; Sasha Ottey; Preeti Dabadghao; Joop S E Laven

doi:10.1016/j.tem.2019.04.006

Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines

Trends Endocrinol Metab. 2019 Jul;30(7):467-478. doi: 10.1016/j.tem.2019.04.006. Epub 2019 May 31.

Authors

Helena Teede¹, Marie Misso², Eliza C Tassone², Didier Dewailly³, Ernest Hy Ng⁴, Ricardo Azziz⁵, Robert J Norman⁶, Marianne Andersen⁷, Stephen Franks⁸, Kathleen Hoeger⁹, Samantha Hutchison¹⁰, Sharon Oberfield¹¹, Duru Shah¹², Femke Hohmann¹³, Sasha Ottey¹⁴, Preeti Dabadghao¹⁵, Joop S E Laven¹⁶

Affiliations

¹ Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University and Monash Health, Locked Bag 29, Clayton, VIC 3168, Australia. Electronic address: Helena.Teede@monash.edu.
² Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University and Monash Health, Locked Bag 29, Clayton, VIC 3168, Australia.
³ Faculté de Médecine, Université de Lille, Lille, France.
⁴ Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China.
⁵ Department of Health Policy, Management, and Behavior, School of Public Health, University at Albany, SUNY, Albany, NY 12144, USA.
⁶ Robinson Research Institute, University of Adelaide and Fertility SA, Adelaide, SA, Australia.
⁷ Department of Endocrinology, Odense University Hospital, Clinical Institute, University of Southern Denmark, 5000 Odense C, Denmark.
⁸ Imperial College London, Institute of Reproductive and Developmental Biology, Hammersmith Hospital, London W12 0NN, UK.
⁹ Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Rochester, Rochester, NY 14642, USA.
¹⁰ Diabetes and Endocrine Units, Monash Health, Clayton, VIC 3168, Australia.
¹¹ Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Columbia University Medical Center, New York, NY 10032, USA.
¹² Gynaecworld, Center for Women's Health and Fertility, Maharashtra 400036, India.
¹³ Huisartsenpraktijk Hohmann & De Vet, Rotterdam 3061, The Netherlands.
¹⁴ PCOS Challenge, Inc., 931 Monroe Drive, NE Suite A-470 Atlanta, GA 30308, USA.
¹⁵ Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India.
¹⁶ Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

PMID: 31160167
DOI: 10.1016/j.tem.2019.04.006

Abstract

Polycystic ovary syndrome (PCOS) affects 8-13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps include large international studies in well-defined populations across the lifespan, clustering of AMH with PCOS features, relationships to long-term health outcomes, and improved quality, assay standardization, and sample handling, all needed to determine cut offs. Here we identify research priorities to address these gaps and enhance AMH utility in PCOS. Once issues are addressed, AMH levels could replace more costly and less accessible ultrasound in PCOS diagnosis.

Keywords: adolescent; adult; anti-Müllerian hormone; diagnostic accuracy; polycystic ovary syndrome; review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anti-Mullerian Hormone / metabolism*
Female
Humans
Ovary / metabolism*
Ovary / pathology
Polycystic Ovary Syndrome / metabolism*
Polycystic Ovary Syndrome / pathology

Substances

Anti-Mullerian Hormone