Triterpene Glycosides from the Seeds of Dolichos lablab

Chem Pharm Bull (Tokyo). 2019;67(6):604-608. doi: 10.1248/cpb.c19-00155.

Abstract

Two new triterpene glycosides (1 and 2), together with nine known triterpene glycosides (3-11), were isolated from the seeds of Dolichos lablab (Leguminosae). The structures of the new compounds were determined by spectroscopic analysis, including two-dimensional NMR spectroscopy, and chromatographic analysis of the hydrolyzed products. The isolated compounds did not show cytotoxicity against HL-60 human leukemia cells and HepG2 human hepatoma cells at sample concentrations of 20 µM.

Keywords: Dolichos lablab; Leguminosae; cytotoxic activity; triterpene glycoside.

MeSH terms

  • Cell Survival / drug effects
  • Dolichos / chemistry*
  • Dolichos / metabolism
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • HL-60 Cells
  • Hep G2 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Seeds / chemistry
  • Seeds / metabolism
  • Solid Phase Extraction
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology

Substances

  • Glycosides
  • Triterpenes