DC offsets in a quadrature mixing structure will affect the system performance. This paper proposes a Hilbert transform-based algorithm to blindly calibrate the DC offsets by filtering the inphase and quadrature signals with the same Hilbert filters. Compared with the traditional averaging-based method, this method consumes less time and resources. Moreover, the proposed method need not interrupt analog-to-digital converter's conversion, featuring the characteristics of high efficiency and good real-time performance. The Matlab simulation results verify the correctness of the proposed algorithm, and finally, an experimental platform is designed in detail to verify the practicability of this blind calibration algorithm.