In-vitro dissolution and microbial inhibition studies on anticancer drug etoposide with β-cyclodextrin

Abstract

In this article, we have reported the inclusion complex behaviors and their pharmaceutical application of anticancer drug property of Etoposide with β-cyclodextrin. The inclusion complex is used to improve the poor aqueous solubility of the anticancer drug Etoposide. The aqueous solubility and in-vitro dissolution studies support to the anticancer drug Etoposide with β-cyclodextrin complex is significantly improves the aqueous solubility. Etoposide:β-cyclodextrin solid-state complexes were prepared by Physical mixture, kneading and solvent evaporation methods, and were characterized by FT-IR, ¹HNMR, XRD, DSC and SEM techniques. In addition, the in-vitro antimicrobial and antibiofilm study of Etoposide drug is a sensible microorganism was significantly increased by an inclusion complexation process. The antibiofilm of anticancer drug Etoposide with β-cyclodextrin studies have been analyzed by confocal laser scanning microscopy.

Keywords: Antimicrobial efficacy; Dissolution rate; Etoposide; Phase solubility; β-Cyclodextrin.