A hydrogenated black TiO2 coating with excellent effects for photothermal therapy of bone tumor and bone regeneration

Wenxin Zhang; Jingping Gu; Kai Li; Jun Zhao; Hongshi Ma; Chengtie Wu; Cheng Zhang; Youtao Xie; Fei Yang; Xuebin Zheng

doi:10.1016/j.msec.2019.04.025

A hydrogenated black TiO₂ coating with excellent effects for photothermal therapy of bone tumor and bone regeneration

Mater Sci Eng C Mater Biol Appl. 2019 Sep:102:458-470. doi: 10.1016/j.msec.2019.04.025. Epub 2019 Apr 10.

Authors

Wenxin Zhang¹, Jingping Gu², Kai Li², Jun Zhao², Hongshi Ma³, Chengtie Wu³, Cheng Zhang⁴, Youtao Xie⁵, Fei Yang⁶, Xuebin Zheng⁷

Affiliations

¹ Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
² Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
³ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
⁴ School of Materials Science and Engineering, Shanghai Institute of Technology, Shanghai 201418, China.
⁵ Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: xieyoutao@mail.sic.ac.cn.
⁶ Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China. Electronic address: feiyangyn@163.com.
⁷ Key Laboratory of Inorganic Coating Materials CAS, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: xbzheng@mail.sic.ac.cn.

PMID: 31147017
DOI: 10.1016/j.msec.2019.04.025

Abstract

The clinical treatment of bone tumors usually brings about residual tumor cells and large bone defects after tumor removal surgery. To solve this problem, it is imperative to develop a novel implant with bi-functions for eliminating the residual tumor cells and repairing bone defects. In this study, hydrogenated black TiO₂ (H-TiO₂) coating with hierarchical micro/nano-topographies is fabricated by induction suspension plasma spraying (ISPS). The fabricated H-TiO₂ coating possessed excellent and controllable photothermal effect in inhibiting the tumor growth under 808 nm NIR laser irradiation in vitro and in vivo. The hierarchical hybrid micro/nano-structured surface and Ti-OH groups improved the adhesion, proliferation, differentiation and osteogenic gene expressions of rat bone mesenchymal stem cells (rBMSCs). These results demonstrate that the H-TiO₂ coating may be a promising implant material for the treatment of bone tumors and bone regeneration.

Keywords: Bone tumor; Micro/nano-structure; Photothermal therapy; Ti-OH groups; Titania.

MeSH terms

Animals
Bone Neoplasms / pathology
Bone Neoplasms / therapy*
Bone Regeneration / drug effects*
Cell Adhesion / drug effects
Cell Differentiation / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Coated Materials, Biocompatible / pharmacology*
Humans
Hydrogenation
Hyperthermia, Induced*
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / drug effects
Mesenchymal Stem Cells / ultrastructure
Mice, Inbred BALB C
Mice, Nude
Osteogenesis / drug effects
Photoelectron Spectroscopy
Phototherapy*
Rats
Titanium / pharmacology*

Substances

Coated Materials, Biocompatible
titanium dioxide
Titanium