Strategic C-C Bond-Forming Dearomatization of Pyridines and Quinolines

Org Lett. 2019 Jun 21;21(12):4459-4463. doi: 10.1021/acs.orglett.9b01247. Epub 2019 May 30.

Abstract

A one-pot protocol for the dearomative double nucleophilic addition to pyridines and quinolines, providing convenient, regioselective and diastereoselective access to tetrahydropyridines and tetrahydroquinolines under reductant-free conditions is described. This method also offers a new strategy for the general dearomatization of nitrogen heteroaromatics.

Publication types

  • Research Support, Non-U.S. Gov't