Diagnostic and prognostic significance of serum CD26 level in Asian women with high-grade serous ovarian carcinoma

Future Oncol. 2019 Jun;15(16):1863-1871. doi: 10.2217/fon-2018-0725. Epub 2019 May 29.

Abstract

Aim: The aim of this study was to reveal the diagnostic and prognostic significance of serum CD26 level in high-grade serous ovarian carcinoma women in China. Methods: There were 229 high-grade serous ovarian carcinoma women and 365 controls. Baseline serum CD26 level was measured using ELISA. A 36-month post-operation follow-up was performed. Results: Baseline serum CD26 level ≤601.5 pg/ml was associated with the increased risk of ovarian carcinoma (OR: 1.67; 95% CI: 1.20-2.32). Baseline serum level of CD26 ≤589.7 pg/ml was related to the elevated risk of cancer death (HR: 1.33; 95% CI: 1.04-1.69). Conclusion: Baseline serum CD26 level might be an independent diagnostic and prognostic marker for high-grade serous ovarian carcinoma.

Keywords: CD26; DPP4; ovarian carcinoma.

MeSH terms

  • Aged
  • Asian People
  • Biomarkers, Tumor*
  • Case-Control Studies
  • Combined Modality Therapy
  • Cystadenocarcinoma, Serous / blood*
  • Cystadenocarcinoma, Serous / diagnosis*
  • Cystadenocarcinoma, Serous / mortality
  • Cystadenocarcinoma, Serous / therapy
  • Dipeptidyl Peptidase 4 / blood*
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Middle Aged
  • Neoplasm Staging
  • Odds Ratio
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / therapy
  • Prognosis
  • ROC Curve

Substances

  • Biomarkers, Tumor
  • Dipeptidyl Peptidase 4