Effect of fitness on cardiac structure and function in overweight and obesity (the FATCOR study)

H Halland; K Matre; E Einarsen; H Midtbø; S Saeed; N Pristaj; M T Lønnebakken; E Gerdts

doi:10.1016/j.numecd.2019.03.012

Effect of fitness on cardiac structure and function in overweight and obesity (the FATCOR study)

Nutr Metab Cardiovasc Dis. 2019 Jul;29(7):710-717. doi: 10.1016/j.numecd.2019.03.012. Epub 2019 Apr 3.

Authors

H Halland¹, K Matre², E Einarsen², H Midtbø³, S Saeed³, N Pristaj², M T Lønnebakken⁴, E Gerdts⁴

Affiliations

¹ Department of Clinical Science, University of Bergen, Bergen, Norway; Norwegian National Advisory Unit on Women's Health, Oslo University Hospital, Oslo, Norway. Electronic address: hildehalland@hotmail.com.
² Department of Clinical Science, University of Bergen, Bergen, Norway.
³ Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
⁴ Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.

PMID: 31138499
DOI: 10.1016/j.numecd.2019.03.012

Abstract

Background and aims: Obesity is associated with reduced left ventricular (LV) systolic myocardial function. We aimed to explore by means of a cross-sectional study whether this effect is offset in the presence of good fitness.

Methods and results: We studied clinical and echocardiographic data from 469 overweight (body mass index [BMI] >27 kg/m²) and obese (BMI ≥30 kg/m²) women and men without known cardiovascular (CV) disease in the FAT associated CardiOvasculaR dysfunction (FATCOR) study. The participants were grouped according to obesity and sex- and age adjusted peak oxygen uptake, obtained by ergospirometry. LV systolic myocardial function was assessed by peak systolic global longitudinal strain (GLS) measured by speckle tracking echocardiography. The association of fitness with GLS was tested in logistic regression analyses and reported as odds ratio (OR) with 95% confidence interval (CI). In the total study population, participants were 47 years old, 60% were women, and mean BMI was 32.0 kg/m². GLS did not differ between fit and unfit subjects within the overweight and obese groups (both p > 0.05), but the overweight fit group had higher GLS (more negative value) compared to the obese unfit group (-20.1 ± 2.6 vs. -19.0 ± 3.0, p < 0.05). In obese subjects, fitness was associated with higher GLS (OR 0.88 [95% CI 0.79-0.99, p < 0.05) in multivariable logistic regression analysis, independent of significant associations with higher arterial stiffness and lower fat percentage (all p < 0.05). In the overweight group, fitness was not significantly associated with GLS.

Conclusion: In obesity, fitness was independently associated with higher GLS, while no association was found in overweight.

Clinical trial registration: URL: http://www.clinicaltrials.govNCT02805478.

Keywords: Cardiorespiratory fitness; Global longitudinal strain; Obesity; Speckle tracking echocardiography; Systolic myocardial function.

Copyright © 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Cardiorespiratory Fitness*
Cross-Sectional Studies
Echocardiography*
Female
Humans
Male
Middle Aged
Obesity / complications*
Obesity / diagnosis
Obesity / physiopathology
Oxygen Consumption
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Ventricular Dysfunction, Left / diagnostic imaging*
Ventricular Dysfunction, Left / etiology
Ventricular Dysfunction, Left / physiopathology
Ventricular Dysfunction, Left / prevention & control
Ventricular Function, Left*
Ventricular Remodeling*

Associated data

ClinicalTrials.gov/NCT02805478