The Diagnostic Pathway From Cognitive Impairment to Dementia in Japan: Quantification Using Real-World Data

Alzheimer Dis Assoc Disord. 2019 Oct-Dec;33(4):346-353. doi: 10.1097/WAD.0000000000000322.

Abstract

Objective: This study aimed to quantify the diagnostic pathway from cognitive impairment (CI) to dementia in Japan.

Methods: This was a real-world, cross-sectional survey of patients with CI and their physicians.

Results: Data for 1107 patients were provided by 106 physicians. Mean time from initial symptoms to the first consultation was 7.4±6.9 months; 42% of patients had moderate/severe CI at first consultation. Mean time from the first consultation to formal diagnosis was 2.9±11.0 months (1.9±8.8 mo if not referred to a secondary physician, and 5.1±14.6 mo if referred). Time from the first consultation to diagnosis was shorter with more severe CI at first consultation (P=0.0072). The highest proportion of patients were diagnosed by neurologists (45.8%). Tests or scales were used to aid diagnosis in 81.2% of patients. There was no association of disease severity and referral to a secondary physician; 30.9% of patients were referred, the majority (57.7%) to a neurologist.

Conclusions: A substantial proportion of patients with dementia in Japan experience CI for some time before consulting a physician. Government policy to increase public understanding and awareness of dementia, and a proposed dementia screening system, should increase the proportion of individuals consulting physicians before disease progression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cognitive Dysfunction / diagnosis*
  • Cross-Sectional Studies
  • Dementia / diagnosis*
  • Female
  • Humans
  • Japan
  • Male
  • Mental Status and Dementia Tests / statistics & numerical data
  • Middle Aged
  • Neuroimaging
  • Neurologists / statistics & numerical data
  • Physicians, Primary Care / statistics & numerical data
  • Prodromal Symptoms*
  • Referral and Consultation / statistics & numerical data*
  • Time Factors