cDC1s: New Orchestrators of Tissue Innate Immunity

Carlos Del Fresno; David Sancho

doi:10.1016/j.it.2019.05.002

cDC1s: New Orchestrators of Tissue Innate Immunity

Trends Immunol. 2019 Jul;40(7):559-561. doi: 10.1016/j.it.2019.05.002. Epub 2019 May 24.

Authors

Carlos Del Fresno¹, David Sancho²

Affiliations

¹ Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid 28029, Spain. Electronic address: carlos.delfresno@cnic.es.
² Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid 28029, Spain. Electronic address: dsancho@cnic.es.

PMID: 31133464
DOI: 10.1016/j.it.2019.05.002

Abstract

Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α. These results reveal a crucial function for cDC1s beyond antigen presentation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antigen Presentation
Bacterial Infections*
Dendritic Cells
Humans
Immunity, Innate
Neutrophils*