Derivatization approaches and applications of pullulan

Sanjay Tiwari; Rahul Patil; Sunil K Dubey; Pratap Bahadur

doi:10.1016/j.cis.2019.04.014

Derivatization approaches and applications of pullulan

Adv Colloid Interface Sci. 2019 Jul:269:296-308. doi: 10.1016/j.cis.2019.04.014. Epub 2019 May 5.

Authors

Sanjay Tiwari¹, Rahul Patil², Sunil K Dubey³, Pratap Bahadur⁴

Affiliations

¹ Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India. Electronic address: tiwarisanju@gmail.com.
² Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India.
³ Department of Pharmacy, Birla Institute of Technology and Science, Pilani 333031, Rajasthan, India.
⁴ Chemistry Department, Veer Narmad South Gujarat University, Surat 395007, Gujarat, India.

PMID: 31128461
DOI: 10.1016/j.cis.2019.04.014

Abstract

Pullulan (PUL), a linear exo-polysaccharide, is useful in industries as diverse as food, cosmetics and pharmaceuticals. PUL presents many favorable characteristics, such as renewable origin, biocompatibility, stability, hydrophilic nature, and availability of reactive sites for chemical modification. With an inherent affinity to asialoglycoprotein receptors, PUL can be used for targeted drug delivery to the liver. Besides, these primary properties have been combined with modern synthetic approaches for developing multifunctional biomaterials. This is evident from numerous studies on approaches, such as hydrophobic modification, cross-linking, grafting and transformation as a polyelectrolyte. In this review, we have discussed up-to-date advances on chemical modifications and emerging applications of PUL in targeted theranostics and tissue engineering. Besides, we offer an overview of its applications in food, cosmetics and environment remediation.

Keywords: Chemical modification; Drug delivery; Polysaccharide; Pullulan; Self assembly; Tissue engineering.

Publication types

Review