The SIZ of Pain

Neuron. 2019 May 22;102(4):709-711. doi: 10.1016/j.neuron.2019.04.040.

Abstract

The site of action potential initiation in sensory neurons remains poorly understood. In this issue of Neuron, Goldstein et al. (2019) identified the location of the sodium-dependent spike initiation zone (Nav-SIZ) in nociceptive neurons, showing its plasticity under inflammatory conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Action Potentials
  • Humans
  • Nociceptors
  • Pain
  • Sensory Receptor Cells*
  • Sodium*

Substances

  • Sodium