ALK-positive histiocytosis with KIF5B-ALK fusion in the central nervous system

Acta Neuropathol. 2019 Aug;138(2):335-337. doi: 10.1007/s00401-019-02027-7. Epub 2019 May 22.

Authors

Calixto-Hope G Lucas¹, Ahmed Gilani², David A Solomon¹, Xiayuan Liang², Ossama M Maher³, Gabriel Chamyan⁴, Bette K Kleinschmidt-Demasters², Arie Perry⁵

Affiliations

¹ Division of Neuropathology, Department of Pathology, University of California, San Francisco, 505 Parnassus Ave, Room M-551, San Francisco, 94143, CA, USA.
² Department of Pathology, University of Colorado, Children's Hospital Colorado, Aurora, CO, USA.
³ Division of Pediatric Neuro-Oncology, Nicklaus Children's Hospital, Miami, FL, USA.
⁴ Department of Pathology, Nicklaus Children's Hospital, Miami, FL, USA.
⁵ Division of Neuropathology, Department of Pathology, University of California, San Francisco, 505 Parnassus Ave, Room M-551, San Francisco, 94143, CA, USA. arie.perry@ucsf.edu.

No abstract available

Keywords: ALK-positive histiocytosis; Central nervous system; Histiocytic; KIF5B-ALK fusion.

Publication types

Case Reports
Letter
Research Support, N.I.H., Extramural

MeSH terms

Brain Diseases / complications
Brain Diseases / diagnostic imaging
Brain Diseases / genetics*
Brain Diseases / surgery
Cerebellar Diseases / diagnostic imaging
Cerebellar Diseases / genetics
Cerebellar Diseases / surgery
Cerebellar Neoplasms / diagnosis
Child
Diagnosis, Differential
Female
Foam Cells / pathology
Histiocytosis / complications
Histiocytosis / diagnostic imaging
Histiocytosis / genetics*
Histiocytosis / surgery
Humans
Magnetic Resonance Imaging
Medulloblastoma / diagnosis
Neoplasm Proteins / analysis
Neoplasm Proteins / genetics*
Neuroimaging
Oncogene Proteins, Fusion / analysis
Oncogene Proteins, Fusion / genetics*
Seizures / etiology

Substances

KIF5B-ALK fusion protein, human
Neoplasm Proteins
Oncogene Proteins, Fusion

Grants and funding

DP5 OD021403/OD/NIH HHS/United States