Abstract
To overcome the slow activation of gemcitabine, we synthesized a DNA-like polygemcitabine (Ge10) strand through solid-phase synthesis, which not only undergoes rapid intracellular degradation to generate active gemcitabine derivatives, but can also self-assemble into nanogels through molecular recognition, rendering them as promising self-delivered nanodrugs for cancer therapy.
MeSH terms
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A549 Cells
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents / toxicity
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Apoptosis
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / chemical synthesis
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Deoxycytidine / pharmacology
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Deoxycytidine / therapeutic use
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Deoxycytidine / toxicity
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Gels / chemical synthesis
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Gels / pharmacology
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Gels / therapeutic use*
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Gels / toxicity
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Gemcitabine
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Humans
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Mice, Nude
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Nanoparticles / therapeutic use
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Nanoparticles / toxicity
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Neoplasms / drug therapy*
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Polymers / chemical synthesis
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Polymers / pharmacology
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Polymers / therapeutic use*
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Polymers / toxicity
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Prodrugs / chemical synthesis
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Prodrugs / pharmacology
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Prodrugs / therapeutic use*
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Prodrugs / toxicity
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Gels
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Polymers
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Prodrugs
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Deoxycytidine
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Gemcitabine