Putting the K+ in K+aloric Restriction

Evan C Lien; Allison N Lau; Matthew G Vander Heiden

doi:10.1016/j.immuni.2019.04.016

Putting the K⁺ in K⁺aloric Restriction

Immunity. 2019 May 21;50(5):1129-1131. doi: 10.1016/j.immuni.2019.04.016.

Authors

Evan C Lien¹, Allison N Lau², Matthew G Vander Heiden³

Affiliations

¹ Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: anlau@mit.edu.
³ Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: mvh@mit.edu.

PMID: 31117009
DOI: 10.1016/j.immuni.2019.04.016

Abstract

Metabolic changes affect T lymphocyte function, and understanding this phenomenon could improve immunotherapy. In a recent paper in Science, Vodnala et al. (2019) report that tumor microenvironmental potassium impairs T cell nutrient uptake and thus causes functional caloric restriction and allows improved anti-tumor immune responses.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Immunotherapy
Killer Cells, Natural*
Neoplasms*
T-Lymphocytes
Tumor Microenvironment

Grants and funding

K99 CA234221/CA/NCI NIH HHS/United States