Antioxidant properties of ALD grown nanoceria films with tunable valency

Ankur Gupta; Tamil S Sakthivel; Craig J Neal; Supriya Koul; Sushant Singh; Akihiro Kushima; Sudipta Seal

doi:10.1039/c9bm00397e

Antioxidant properties of ALD grown nanoceria films with tunable valency

Biomater Sci. 2019 Jul 1;7(7):3051-3061. doi: 10.1039/c9bm00397e. Epub 2019 May 22.

Authors

Ankur Gupta¹, Tamil S Sakthivel², Craig J Neal¹, Supriya Koul¹, Sushant Singh², Akihiro Kushima³, Sudipta Seal⁴

Affiliations

¹ Department of Materials Science and Engineering, University of Central Florida, 12760 Pegasus Blvd., P.O. Box 162450, Orlando, Florida 32816, USA. Sudipta.Seal@ucf.edu guptaankur@knights.ucf.edu and Advanced Materials Processing and Analysis Center, University of Central Florida, 4000 Central Florida Blvd., P.O. Box 162455, Orlando, Florida 32816, USA.
² Advanced Materials Processing and Analysis Center, University of Central Florida, 4000 Central Florida Blvd., P.O. Box 162455, Orlando, Florida 32816, USA.
³ Department of Materials Science and Engineering, University of Central Florida, 12760 Pegasus Blvd., P.O. Box 162450, Orlando, Florida 32816, USA. Sudipta.Seal@ucf.edu guptaankur@knights.ucf.edu and Advanced Materials Processing and Analysis Center, University of Central Florida, 4000 Central Florida Blvd., P.O. Box 162455, Orlando, Florida 32816, USA and Nanoscience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, Florida 32816, USA.
⁴ Department of Materials Science and Engineering, University of Central Florida, 12760 Pegasus Blvd., P.O. Box 162450, Orlando, Florida 32816, USA. Sudipta.Seal@ucf.edu guptaankur@knights.ucf.edu and Advanced Materials Processing and Analysis Center, University of Central Florida, 4000 Central Florida Blvd., P.O. Box 162455, Orlando, Florida 32816, USA and Nanoscience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, Florida 32816, USA and College of Medicine, University of Central Florida, Orlando, Florida 32827, USA.

PMID: 31115397
DOI: 10.1039/c9bm00397e

Abstract

Herein, we provide the first account of a method to control cerium oxide's mixed valence states (as Ce³⁺ to Ce⁴⁺ ratio) in ultra-thin films formed via atomic layer deposition (ALD). It is determined that modulation of Ce³⁺/Ce⁴⁺ ratio occurs with respect to film thickness and is analogous to the change in surface chemistry observed for cerium oxide nanoparticles with varying particle diameter. The influence of film thickness on enzyme-mimetic radical scavenging is also characterized. Higher film thicknesses show 9-fold increase in catalytic activity. In vitro biocompatibility (apoptosis < 4%) and electrochemical biosensing (lowest concentration: 18 ppt) studies were performed to demonstrate the potential of ALD-grown nanoceria films for biomedical applications.

MeSH terms

Antioxidants / chemistry*
Antioxidants / pharmacology*
Antioxidants / toxicity
Apoptosis / drug effects
Cell Line
Cerium / chemistry*
Cerium / pharmacology*
Cerium / toxicity
Humans
Hydrogen Peroxide / analysis
Nanoparticles / chemistry*
Nanotechnology*
Particle Size

Substances

Antioxidants
Cerium
ceric oxide
Hydrogen Peroxide