Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Benedetta Mariotti; Federico Meconi; Raffaele Palmieri; Eleonora De Bellis; Serena Lavorgna; Tiziana Ottone; Vincenza Martini; Francesco Lo-Coco; Laura Cicconi

doi:10.1155/2019/6707506

Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations

Case Rep Hematol. 2019 Apr 11:2019:6707506. doi: 10.1155/2019/6707506. eCollection 2019.

Authors

Benedetta Mariotti¹, Federico Meconi¹, Raffaele Palmieri¹, Eleonora De Bellis¹, Serena Lavorgna¹, Tiziana Ottone¹, Vincenza Martini², Francesco Lo-Coco¹, Laura Cicconi¹

Affiliations

¹ Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.
² UOC Ematologia, Ospedale "Fabrizio Spaziani", Frosinone, Italy.

Abstract

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.

Publication types

Case Reports