In 2016, an upsurge of neurologic disease associated with infection with multirecombinant enterovirus A71 subgenogroup C1 lineage viruses was reported in France. These viruses emerged in the 2000s; 1 recombinant is widespread. This virus lineage has the potential to be associated with a long-term risk for severe disease among children.
Keywords: 3Dpol; 5′ UTR; C1 subgenogroup; C1v2015 lineage; EV-A71; France; children; coxsackievirus; enterovirus; enterovirus infection; epidemiologic monitoring; genetic recombination; genomic region P1; most recent common ancestor; neurologic disease; neurologic manifestations; viruses; whole-genome sequencing.