A novel circular RNA hsa_circ_0008035 contributes to gastric cancer tumorigenesis through targeting the miR-375/YBX1 axis

Shifang Huang; Xiaolin Zhang; Bingsheng Guan; Peng Sun; Chong Tsz Hong; Juzheng Peng; Shaohui Tang; Jingge Yang

A novel circular RNA hsa_circ_0008035 contributes to gastric cancer tumorigenesis through targeting the miR-375/YBX1 axis

Am J Transl Res. 2019 Apr 15;11(4):2455-2462. eCollection 2019.

Authors

Shifang Huang¹, Xiaolin Zhang², Bingsheng Guan³, Peng Sun³, Chong Tsz Hong³, Juzheng Peng³, Shaohui Tang⁴, Jingge Yang³

Affiliations

¹ Intensive Care Unit, First Affiliated Hospital, Jinan University Guangzhou 510630, China.
² Department of Gastrointestinal Surgery, Heze Municipal Hospital Heze 274031, China.
³ Department of Gastrointestinal Surgery, Jinan University Guangzhou 510630, China.
⁴ Department of Gastroenterology, Jinan University Guangzhou 510630, China.

PMID: 31105852
PMCID: PMC6511772

Abstract

Circular RNAs (circRNAs) play an important regulatory role in a variety of human cancers, including gastric cancer. The mechanisms for the circRNAs in gastric cancers are not fully understood. This study aims to uncover the mechanism by which circRNAs regulate gastric cancer tumorigenesis. Among the microarray data, we screened dysregulated circRNAs and identified an up-regulated circRNA, hsa_circ_0008035. Functionally, the hsa_circ_0008035 silencing by the siRNA transfection inhibited the proliferation and invasion of gastric cancer cells. Mechanically, hsa_circ_0008035 acted as a sponge for the miR-375 and absorbed its expression, and miR-375 was found to target YBX1 3'-UTR, constructing a hsa_circ_0008035/miR-375/YBX1 axis. Taken together, these findings are evidence that circRNA hsa_circ_0008035 promotes gastric cancer cell proliferation and invasion by regulating miR-375/YBX1.

Keywords: Gastric cancer; YBX1; hsa_circ_0008035; miR-375.