Acute epiglottitis/supraglottitis is an acute disease with potential life-threatening complications such as airway obstruction. We present the case of an 85 year old woman hospitalized due to pain in her neck, odynophagia and unclear speech. Bacteraemia with Neisseria meningitidis type Y was detected. The patient was treated with Ceftriaxone and corticosteroids with resolution of symptoms. In a literature review we found only 21 additional cases of epiglottitis and bacteraemia due to Neisseria meningitidis, 52% of which were caused by serogroup Y. All the patients with supraglottitis caused by Neisseria meningitidis were bacteremic, and 69% of them suffered from airway compromise. Routine drawing of blood culture in supraglottitis patients can lead to higher detection rates of Neisseria meningitidis cases.