Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity

Allison C Billi; Johann E Gudjonsson

doi:10.1016/j.cell.2019.04.033

Overriding the Immune System's Sweet Tooth: Fatty Acids Rile Up Innate Immunity

Cell. 2019 May 16;177(5):1088-1090. doi: 10.1016/j.cell.2019.04.033.

Authors

Allison C Billi¹, Johann E Gudjonsson²

Affiliations

¹ Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
² Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: johanng@med.umich.edu.

PMID: 31100264
DOI: 10.1016/j.cell.2019.04.033

Abstract

Mogilenko et al. dissect mechanisms by which fatty acids lead to a state of heightened innate immunity and inflammation. They reveal a metabolic adaptation to elevated fatty acids that involves a shift in the balance between glycolysis and oxidative phosphorylation and activation of the unfolded protein response, linking the high-fat Western diet to systemic inflammatory disease.

Publication types

Comment

MeSH terms

Cues*
Fatty Acids*
Immune System
Immunity, Innate
Unfolded Protein Response

Substances

Fatty Acids

Grants and funding

T32 AR007197/AR/NIAMS NIH HHS/United States