BMPing Up Healing Capacity with FKBP12 Ligand

Charles H Williams; Charles C Hong

doi:10.1016/j.chembiol.2019.05.001

BMPing Up Healing Capacity with FKBP12 Ligand

Cell Chem Biol. 2019 May 16;26(5):619-620. doi: 10.1016/j.chembiol.2019.05.001.

Authors

Charles H Williams¹, Charles C Hong²

Affiliations

¹ Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
² Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: charles.hong@som.umaryland.edu.

PMID: 31100260
DOI: 10.1016/j.chembiol.2019.05.001

Abstract

While the wound healing property of the macrolide FK506 is well known, the underlying mechanism has been elusive. In this issue of Cell Chemical Biology, Peiffer et al. (2019) utilize FKBP12 ligand to demonstrate that wound healing effects of FK506 occur via activation of the BMP (bone morphogenic protein) signaling pathway.

Publication types

Comment

MeSH terms

Ligands
Signal Transduction
Tacrolimus Binding Protein 1A*
Tacrolimus*
Wound Healing

Substances

Ligands
Tacrolimus Binding Protein 1A
Tacrolimus

Grants and funding

R01 GM118557/GM/NIGMS NIH HHS/United States