High-Grade Endometrial Carcinomas: Classification with Molecular Insights

Joseph W Carlson; Denis Nastic

doi:10.1016/j.path.2019.02.003

High-Grade Endometrial Carcinomas: Classification with Molecular Insights

Surg Pathol Clin. 2019 Jun;12(2):343-362. doi: 10.1016/j.path.2019.02.003.

Authors

Joseph W Carlson¹, Denis Nastic²

Affiliations

¹ Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17176, Sweden; Department of Clinical Pathology and Cytology, Karolinska University Hospital, Radiumhemmet P1:02, Stockholm SE-17176, Sweden. Electronic address: joseph.carlson@ki.se.
² Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17176, Sweden; Department of Clinical Pathology and Cytology, Karolinska University Hospital, Radiumhemmet P1:02, Stockholm SE-17176, Sweden.

PMID: 31097108
DOI: 10.1016/j.path.2019.02.003

Abstract

This article provides an overview of the current diagnosis of endometrial carcinoma subtypes and provides updates, including the most recent molecular findings from The Cancer Genome Atlas and others. Interpretation of relevant immunohistochemistry and critical diagnostic differential diagnosis with pitfalls are discussed.

Keywords: Endometrial cancer; MSI; Molecular pathologic assessment; POLE; Prognosis; TCGA; p53.

Publication types

Review

MeSH terms

Biomarkers, Tumor / metabolism
Diagnosis, Differential
Endometrial Neoplasms / diagnosis*
Endometrial Neoplasms / genetics
Endometrial Neoplasms / immunology
Endometrial Neoplasms / pathology
Female
Humans
Immunophenotyping
Mutation
Neoplasm Grading
Prognosis

Substances

Biomarkers, Tumor