Delivery of phytochemicals by liposome cargos: recent progress, challenges and opportunities

J Microencapsul. 2019 May;36(3):215-235. doi: 10.1080/02652048.2019.1617361. Epub 2019 Jun 19.

Abstract

Bio-availability is a major concern in delivery of dietary phytochemicals for better bio-efficacy. The reduced bio-availability of food bioactive compounds is evident due to degradation during human digestion process which involves liberation, absorption, distribution, metabolism and elimination. The bio-efficacy of any nutrient can be increased by increasing bio-availability. Different technologies are available for engineered efficient delivery systems; still many challenges remain with advancement of delivery systems. The ease of preparedness and adaptability of liposomes has resulted in wide-range of applicability and acceptability in scientific field, especially as delivery vehicles. In view, of properties like biocompatibility and biodegradability, liposomes have been modified with different usable methodologies for delivery of phytochemicals. The aim of this review is to abridge liposomes, methods of preparation, their application as delivery cargo in dietary phytochemicals, result of using different preparation techniques on properties.

Keywords: Liposomes delivery systems encapsulation phytochemicals bioactive molecules.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Availability
  • Drug Delivery Systems / methods
  • Humans
  • Liposomes / chemistry
  • Liposomes / metabolism*
  • Phytochemicals / administration & dosage*
  • Phytochemicals / pharmacokinetics

Substances

  • Liposomes
  • Phytochemicals