Progress in biosensor based on DNA-templated copper nanoparticles

Zhihe Qing; Ailing Bai; Shuohui Xing; Zhen Zou; Xiaoxiao He; Kemin Wang; Ronghua Yang

doi:10.1016/j.bios.2019.05.014

Progress in biosensor based on DNA-templated copper nanoparticles

Biosens Bioelectron. 2019 Jul 15:137:96-109. doi: 10.1016/j.bios.2019.05.014. Epub 2019 May 7.

Authors

Zhihe Qing¹, Ailing Bai², Shuohui Xing², Zhen Zou³, Xiaoxiao He⁴, Kemin Wang⁴, Ronghua Yang⁵

Affiliations

¹ Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China. Electronic address: qingzhihe@hnu.edu.cn.
² Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China.
³ Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, People's Republic of China.
⁴ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, People's Republic of China.
⁵ Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, 410114, PR China; State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, People's Republic of China. Electronic address: Yangrh@pku.edu.cn.

PMID: 31085403
DOI: 10.1016/j.bios.2019.05.014

Abstract

During the last decades, by virtue of their unique physicochemical properties and potential application in microelectronics, biosensing and biomedicine, metal nanomaterials (MNs) have attracted great research interest and been highly developed. Deoxyribonucleic acid (DNA) is a particularly interesting ligand for templating bottom-up nanopreparation, by virtue of its excellent properties including nanosized geometry structure, programmable and artificial synthesis, DNA-metal ion interaction and powerful molecular recognition. DNA-templated copper nanoparticles (DNA-CuNPs) has been developed in recent years. Because of its advantages including simple and rapid preparation, high efficiency, MegaStokes shifting and low biological toxicity, DNA-CuNPs has been highly exploited for biochemical sensing from 2010, especially as a label-free detection manner, holding advantages in multiple analytical technologies including fluorescence, electrochemistry, surface plasmon resonance, inductively coupled plasma mass spectrometry and surface enhanced Raman spectroscopy. This review comprehensively tracks the preparation of DNA-CuNPs and its application in biosensing, and highlights the potential development and challenges regarding this field, aiming to promote the advance of this fertile research area.

Keywords: Biosensor; Copper nanoparticles; DNA; Template.

Publication types

Review

MeSH terms

Biosensing Techniques*
Copper / chemistry*
DNA / chemistry
DNA / isolation & purification*
Fluorescence
Fluorescent Dyes / chemistry
Metal Nanoparticles / chemistry*
Spectrometry, Fluorescence
Surface Plasmon Resonance

Substances

Fluorescent Dyes
Copper
DNA