Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma

Cells. 2019 May 10;8(5):441. doi: 10.3390/cells8050441.

Abstract

Keywords: multiple myeloma; bone disease; osteogenesis; adipogenesis; adipose-derived stem cells; bone marrow; senescence; Dickkopf-related protein 1; systemic disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cell Differentiation
  • Cells, Cultured
  • Cellular Senescence
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Mesenchymal Stem Cells / metabolism*
  • Mesenchymal Stem Cells / pathology
  • Middle Aged
  • Multiple Myeloma / metabolism*
  • Osteoblasts / metabolism*
  • Osteoblasts / pathology
  • Osteogenesis

Substances

  • DKK1 protein, human
  • Intercellular Signaling Peptides and Proteins