Unprecedented Rh(III)-catalyzed C-H bond difluorovinylation of indoles has been successfully developed, and this method provided an example of direct difluorovinylation reaction through C-H bond activation which was rarely reported. In this context, N-ethoxycarbamoyl served as the directing group and 2,2-difluorovinyl tosylates were used for the construction of difluorovinyl-substituted indoles. This method provided a practical strategy for difluorovinylation of indoles with moderate to good yields and is characterized by the broad synthetic utility, mild conditions, and high efficiency.