We propose a mechanism for myelin plasticity that would complement synaptic plasticity by adjusting conduction velocity for optimal spike-time arrival. In the proposed treadmilling model, myelin sheath thickness is a dynamic balance between the rates of new myelin deposited adjacent to the axon and removal of the outermost layer.
Keywords: astrocyte; myelin plasticity; neurofascin155; oligodendrocyte; spike-time dependent plasticity; thrombin.
Published by Elsevier Ltd.