Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice

Biosci Rep. 2019 May 23;39(5):BSR20190301. doi: 10.1042/BSR20190301. Print 2019 May 31.

Abstract

The present study aimed to investigate the protective effects of ganoderic acid A (GAA) on lipopolysaccharide (LPS)-induced acute lung injury. In mouse model of LPS-induced acute lung injury, we found that GAA led to significantly lower lung wet-to-dry weight ratio and lung myeloperoxidase activity, and attenuated pathological damages. In addition, GAA increased superoxide dismutase activity, but decreased malondialdehyde content and proinflammatory cytokines levels in the bronchoalveolar lavage fluid. Mechanistically, GAA reduced the activation of Rho/ROCK/NF-κB pathway to inhibit LPS-induced inflammation. In conclusion, our study suggests that GAA attenuates acute lung injury in mouse model via the inhibition of Rho/ROCK/NF-κB pathway.

Keywords: ganoderic acid A; lipopolysaccharide; lung injury; nuclear factor kappaB; rho-associated protein kinases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Heptanoic Acids / pharmacology*
  • Lanosterol / analogs & derivatives*
  • Lanosterol / pharmacology
  • Lipopolysaccharides / toxicity*
  • Lung Injury / chemically induced
  • Lung Injury / metabolism
  • Lung Injury / pathology
  • Lung Injury / prevention & control*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • NF-kappa B / metabolism
  • Signal Transduction / drug effects*
  • rho GTP-Binding Proteins / metabolism
  • rho-Associated Kinases / metabolism

Substances

  • Heptanoic Acids
  • Lipopolysaccharides
  • NF-kappa B
  • Lanosterol
  • ganoderic acid A
  • rho-Associated Kinases
  • rho GTP-Binding Proteins