Wearable Devices for Single-Cell Sensing and Transfection

Lingqian Chang; Yu-Chieh Wang; Faheem Ershad; Ruiguo Yang; Cunjiang Yu; Yubo Fan

doi:10.1016/j.tibtech.2019.04.001

Wearable Devices for Single-Cell Sensing and Transfection

Trends Biotechnol. 2019 Nov;37(11):1175-1188. doi: 10.1016/j.tibtech.2019.04.001. Epub 2019 May 6.

Authors

Lingqian Chang¹, Yu-Chieh Wang², Faheem Ershad³, Ruiguo Yang⁴, Cunjiang Yu⁵, Yubo Fan⁶

Affiliations

¹ School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Institute of Nanotechnology for Single Cell Analysis (INSCA), Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China; Department of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA.
² Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
³ Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
⁴ Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, NE 68588, USA; Center for Integrated Biomolecular Communications, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. Electronic address: ryang6@unl.edu.
⁵ Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA; Department of Mechanical Engineering, Electrical and Computer Engineering, University of Houston, Houston, TX 77204, USA; Program of Materials Science and Engineering, University of Houston, Houston, TX 77204, USA. Electronic address: cyu13@centeral.uh.edu.
⁶ School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Institute of Nanotechnology for Single Cell Analysis (INSCA), Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China. Electronic address: yubofan@buaa.edu.cn.

Abstract

Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields.

Keywords: biosensors; drug delivery; gene transfection; single cell; wearable electronics.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Biosensing Techniques / instrumentation*
Drug Delivery Systems / instrumentation
Humans
Monitoring, Physiologic / instrumentation*
Skin / metabolism
Transfection / instrumentation*
Wearable Electronic Devices

Abstract

Publication types

MeSH terms

Grants and funding