Axons Navigate Noise with 190RhoGAP

Pavol Zelina; R Jeroen Pasterkamp

doi:10.1016/j.neuron.2019.04.024

Axons Navigate Noise with 190RhoGAP

Neuron. 2019 May 8;102(3):512-514. doi: 10.1016/j.neuron.2019.04.024.

Authors

Pavol Zelina¹, R Jeroen Pasterkamp²

Affiliations

¹ Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, the Netherlands.
² Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, the Netherlands. Electronic address: r.j.pasterkamp@umcutrecht.nl.

PMID: 31071282
DOI: 10.1016/j.neuron.2019.04.024

Abstract

In this issue of Neuron, Bonanomi et al. (2019) investigate how navigating axons ignore irrelevant guidance signals. They show that the binding of p190RhoGAP to DCC suppresses inappropriate responses to Netrin-1, allowing motor axons to exit the embryonic spinal cord.

Publication types

Comment

MeSH terms

Axon Guidance*
Axons
DCC Receptor
Nerve Growth Factors*
Netrin-1
Tumor Suppressor Proteins

Substances

DCC Receptor
Nerve Growth Factors
Tumor Suppressor Proteins
Netrin-1