Background: Type-II endometrial cancer is an estrogen independent and one of the most lethal types of cancer having poor prognosis. Adipokines play a crucial role in the triggering Type-II EMC. In addition, adipokines modulators, therefore, may have beneficial effects in the treatment of Type-II endometrial cancer, which was clinically evidenced.
Areas covered: This review presents the role of various adipokines involved and also the suitable modulators to treat Type-II endometrial cancer.
Conclusion: In the present review, we try to discuss the role of individual adipokines in the pathogenesis of Type-II endometrial cancer, and also the possible beneficial effects of adipokines modulator in the treatment of Type-II endometrial cancer.
Keywords: Adipokine modulators; Adipokines; Adiponectin; Cancer; Endometrial cancer; Leptin; Resistin; Type-II EMC; Visfatin.